Diseases affecting large joints include the following: 1. Osteoarthritis, which is common in the hip and knee joints. This is due to excessive wear and tear of the joints, resulting in significant degeneration of the cartilage, narrowing of the joint space, osteomalacia and calcification, resulting in pain in the joints and unfavorable movement of the joints; 2. Tuberculous arthritis, which is due to infection with Mycobacterium tuberculosis. Usually need to carry out anti-tuberculosis treatment, such as isoniazid, rifampicin, pyrazinamide, ethambutol, etc.; 3, gouty arthritis, mainly due to the human body purine metabolism disorders, resulting in uric acid increase, will lead to the joints parts of the more uric acid salt deposition, therefore, there will be joint inflammation; 4, rheumatoid arthritis, this is due to the human body infected with streptococcus bacteria lead to the human body large joints parts of the pain and unfavorable activities. Wandering pain, usually in the acute stage of intravenous penicillin drugs, for effective anti-infection. In addition, in normal times must pay attention to rest, keep warm, can be physiotherapy and other measures, can effectively relieve.