Meningeal irritation is more likely to occur in purulent bacterial infections, tuberculous meningitis, and subarachnoid hemorrhage, but there is no such thing as the disease that is most likely to cause meningeal irritation due to the large differences between individuals. 1. Purulent bacterial infection: patients will have fever, chills, meningeal irritation sign, severe headache and other symptoms, mainly in children. For treatment, doctors will use antibacterial drugs to control the disease. 2. Tuberculous meningitis: the disease is insidious, and the severity of the disease varies, mainly manifested as low-grade fever, night sweats, loss of appetite, fatigue, mental instability and other symptoms. In severe cases, meningeal irritation, coma and paralysis may occur. For treatment, doctors will use anti-tuberculosis drugs. 3. Subarachnoid hemorrhage: Subarachnoid hemorrhage is mainly manifested by severe headache, eye bleeding, etc. It is also prone to meningeal irritation sign. Meningeal irritation sign is a more serious clinical manifestation, patients will have stiff neck, severe headache, vomiting, fainting and even coma and other symptoms. It is important to seek prompt medical attention, cooperate with the doctor to find out the cause of meningeal irritation and provide targeted treatment.