The main difference between povidone-iodine and boric acid lotion is that they have different mechanisms of action and different bactericidal abilities. Povidone-iodine has a broad-spectrum bactericidal effect, which can denature the proteins of pathogens and kill bacteria, fungi, protozoa and some viruses, etc. It is mainly used for the disinfection of skin and mucous membranes, and can also be used for the treatment of skin infections and so on. The inhibitory effect of boric acid lotion on bacteria and fungi is weak, mainly through the combination of acidity and the amino group of protein in bacteria to play an inhibitory effect. Boric acid lotion is less irritating, and can be used to clean damaged skin, mucous membranes, and for acute dermatitis, eczema oozing wet compresses, can also be used for stomatitis, pharyngitis gargle. Both may cause skin allergic reactions when used, and are prohibited for those who are allergic to these two drugs. Although povidone-iodine and boric acid lotion are more common and widely used, but the use of medication should follow the doctor’s instructions, not self-medication.