Patients appearing in the case of palms peeling and cracking, may be caused by ringworm, hand eczema, exfoliative keratolysis, etc., can use general treatment, medication and other measures to help recovery. 1. Ringworm: ringworm is a superficial skin fungal infection of the hands caused by dermatophytes, mainly involving interphalangeal, palm and other parts, mainly manifested as blisters, dandruff, skin roughness and thickening, sometimes causing palm roughness, peeling, cracking, etc., palm peeling and cracking may be caused by ringworm. It is necessary to pay attention to daily to keep hands clean and dry, external use of terbinafine hydrochloride cream, amorphophine ointment and other drugs, oral itraconazole and other drugs if necessary. 2. Hand eczema: hand eczema is an allergic inflammatory reaction of the skin of the hand, mainly manifested as asymmetric patches of both hands, characterized by small blisters, pimples and other lesions, accompanied by flaking, peeling, cracking, and flaky skin thickening and other symptoms. Pay attention to avoid contact with allergenic substances, external use of mometasone furoate, halometasone and other drugs, if necessary, oral antihistamine drugs such as loratadine. 3. Exfoliative keratolysis: it is a superficial exfoliative dermatosis of the hands and feet, mainly manifested in seasonal recurrent scaling of the palm and plantar areas, cracked hands, peeling and other symptoms. Daily attention should be paid to hands moisturizing care, such as the use of urea cream, avoid contact with irritating substances, generally do not need special treatment. If necessary, oral vitamin A or vitamin E and other medication. It is recommended that patients seek medical examination in a timely manner to clarify the cause of the disease and then follow the doctor’s instructions for targeted treatment, do not self-medication.