A small number of patients with cryptogenic nephritis can be self-healed, and the time of self-healing is uncertain for several years. Cryptogenic nephritis only manifests as mild proteinuria and (or hematuria) clinically, and patients do not have hypertension, edema and renal impairment, no specific treatment is needed until the cause is clearly identified, and attention should be paid to avoiding factors aggravating renal damage, as well as regular rechecks. Most patients with cryptogenic nephritis have a good prognosis, and only some of them may be aggravated. It should be noted that a few patients with cryptogenic nephritis can recover spontaneously, but the time of self-healing is not certain. Some patients with worsening proteinuria, hypertension and renal hypoplasia should have renal biopsy as soon as possible for clear diagnosis, to determine the type of pathology and timely treatment. Patients with cryptogenic nephritis should go to the hospital in time for consultation and treatment under the guidance of professional physicians, regular review and regular treatment.