Whether cryptogenic nephritis can be kept for a lifetime without deterioration needs to be judged with the combination of condition and treatment effect. If the patient’s condition is mild, or timely treatment, cryptogenic nephritis can be non-worsening for a lifetime. If the patient has increased urine protein, high blood pressure and kidney damage, and the treatment effect is not good, then cryptogenic nephritis may develop and deteriorate. Occult nephritis, i.e., asymptomatic hematuria and/or proteinuria, refers to a group of glomerular diseases manifested only by glomerulonephritic hematuria and/or mild-to-moderate proteinuria without edema, hypertension, and renal impairment, which are usually detected and diagnosed by laboratory tests. If the patient’s condition is mild or treated in time, the renal function of most patients can be maintained stable for a long time, and a few patients will be cured automatically, at which time cryptogenic nephritis can be kept from worsening for the rest of the life. Some patients have increased urinary protein, hypertension and kidney damage, poor treatment effect, kidney function may progress, at this time usually not can not deteriorate for the rest of their life. Patients with cryptogenic nephritis are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.