IgA nephropathy is a pathological diagnosis and cryptoglomerulonephritis is a clinical diagnosis, and the difference between the two is mainly in clinical manifestations and pathological changes. The clinical manifestations of IgA nephropathy may be manifested as cryptogenic or chronic glomerulonephritis, often presenting as asymptomatic hematuria with or without proteinuria. The main manifestation is episodic hematuria of the flesh, which may last for hours or days. The pathology of cryptoglomerulonephritis can also manifest as IgA nephropathy. The pathology of IgA nephropathy is characterized by proliferation of glomerular mesangial cells and increased stroma. The pathologic changes are varied, with varying degrees of severity, and can involve almost all pathological types of glomerulonephritis, such as mesangial proliferative glomerulonephritis, mild lesion type, focal proliferative glomerulonephritis, and so on. Cryptoglomerulonephritis is usually not easy to detect and is mainly detected by physical examination. The main clinical manifestations of cryptogenic nephritis are mainly microscopic hematuria, which can be accompanied by a small amount of proteinuria, no renal edema, renal hypertension, and stable and normal renal function for a long time. Whether you are suffering from IgA nephropathy or cryptogenic nephritis, you should consult a doctor in time and take active treatment under the guidance of a physician.