There is no clinical term for advanced pneumoconiosis, but stage III pneumoconiosis is indeed the most severe stage of pneumoconiosis on imaging. On CT, early pneumoconiosis patients mainly show diffuse interstitial fibrosis, and small diffuse shadows can be seen on both lungs. As the disease progresses, patients will develop some pleural thickening, increased fibrosis, and some of them will gather into clusters. By stage III pneumoconiosis, X-ray examination will show one of the following manifestations: (1) Large shadows with a long diameter of not less than 20 mm and a short diameter of more than 10 mm; (2) The presence of small shadows with an overall density of grade 3, spread over more than 4 lung regions and clustering of small shadows; (3) Having small shadows of overall denseness grade 3, distributed over more than 4 lung areas and with large shadows; (4) Exposure to asbestos dust with small shadows of overall intensity grade 3, spread over more than 4 lung areas, and at the same time the sum of the lengths of single or bilateral multiple pleural patches exceeds one-half of the length of the unilateral chest wall or involves the heart margins so that some of them appear fluffy. Patients with pneumoconiosis should actively get out of the dusty environment and cooperate with doctors for treatment. Most patients can improve their quality of life and prolong their life span after standardized treatment. It is recommended that patients with pneumoconiosis III should seek medical treatment in time and under the guidance of doctors.