Patients with a flesh pimple on the knee, based on different common clinical reasons, often have the following conditions: a. When serious trauma at the knee, can cause local trauma in the healing process, accompanied by abnormal proliferation of inflammatory granulation tissue, manifested as local flesh pimple-like changes, at this time can be through the local external application of such as Yi Jin Huang ointment, ichthyol ointment, to promote the local inflammatory granulation tissue of their own absorption, for the larger volume For larger inflammatory granulomas, local swelling and pain can be considered for surgical excision. The patient’s knee with skin malignant tumor proliferation can also be manifested as localized flesh pimple-like changes, at this time, it is recommended that the patient perform surgery as soon as possible to completely remove the flesh pimple, local radiotherapy treatment, as far as possible to kill the cancer cells in the body, prolonging the patient’s life, the effect of treatment for patients with early disease is still possible.