Contraindications to systemic chemotherapy include: 1. very poor general condition with cachexia; 2. serious liver, kidney, heart and lung dysfunction; 3. leukocyte reduction to 4×109/L, platelets less than 50×109/L, bleeding tendency; 4. other serious complications, such as serious infection, gallbladder perforation, gastrointestinal bleeding, etc. Second, radiotherapy: 1, intraoperative radiotherapy, postoperative localization radiotherapy and staged internal irradiation, etc. Radical dose irradiation radiotherapy has certain effect on advanced cholangiocarcinoma because it can denature and necrotize cancer cells and inhibit their growth, which can prolong the survival of advanced cholangiocarcinoma patients. Chinese medicine treatment for bile duct cancer Combination of Chinese and Western medicine treatment can improve the efficacy of gallbladder cancer, especially for advanced gallbladder cancer patients with unsatisfactory surgical effect and low sensitivity of chemotherapy, if combined with Chinese medicine treatment, it can improve the general condition of patients and prolong the survival period. 2.After middle and late stage surgery, it can be supplemented with Chinese medicine treatment, which can restore the patient’s physique to a certain extent by supporting the righteousness and eliminating the evil, benefiting the qi, nourishing the blood and harmonizing the spleen and stomach. Chemotherapy and Chinese medicine can reduce the toxic side effects of chemotherapy drugs and improve the immune system to make the patient tolerate the treatment, and at the same time have the effect of adding therapeutic effects. The combination of radiotherapy with Chinese medicine can reduce the damage of radiotherapy, promote the recovery of the normal function of the body, strengthen the body and improve the therapeutic effect.