In early pregnancy, if progesterone drops, it is often clinically caused by the following reasons: 1. It is caused by the pregnant woman’s own endocrine relationship, because of insufficient luteinizing function, so after laboratory tests, a decreasing trend of progesterone will be found. If intrauterine pregnancy has been confirmed, it is recommended that active progesterone supplementation will improve the situation. 2. If intrauterine pregnancy has not been confirmed by ultrasound, it is likely to be caused by ectopic pregnancy. In the case of ectopic pregnancy, the progesterone in the body will tend to decline. It is recommended to have an ultrasound examination as soon as possible and to combine it with the clinical results of blood HCG monitoring to give a comprehensive analysis. In addition, it is recommended to rule out the possibility of biochemical pregnancy when progesterone decreases in clinical practice.