In the early stage of pregnancy, there are several reasons for lower progesterone: first of all, consider the insufficient luteal function in the body, if the progesterone value is lower than 25ng/ml, ultrasound should be performed to check whether the embryo is developing normally, if there is no abdominal pain and vaginal bleeding symptoms in life, it is recommended to do the recheck after 1 week. The progesterone value in pregnant women’s body is pulsating, if the time of conducting the examination is the low period of progesterone value, it may lead to the decrease of the value. If symptoms of abdominal pain and vaginal bleeding occur, it may indicate the risk of preterm miscarriage, and progesterone should be given for fetal preservation treatment under the advice of a physician. Secondly, lower progesterone in early pregnancy consider whether it is caused by thyroid dysfunction, and insufficient ovarian secretion. Finally, women who have undergone uterine operations before pregnancy and have a history of miscarriage, which affects the endometrium, are also prone to lower progesterone during pregnancy.