Benadryl hydrochloride tablets and antihypertensive drugs can be used in combination, and are often combined with beta-blockers, diuretics, calcium antagonists and so on. 1. with β-blockers: hypertension combined with atrial fibrillation alone Benadryl hydrochloride tablets to control blood pressure is not ideal, can be added with β-blocker therapy, such as Bisoprolol. β-blockers can lower blood pressure and can control atrial fibrillation of the ventricular rate. 2. Combined with diuretics: Benadryl hydrochloride tablets are prone to induce hyperkalemia, can be combined with diuretics, such as hydrochlorothiazide to control blood pressure. Hydrochlorothiazide can counteract the hyperkalemia side effect of Benadryl Hydrochloride Tablets. 3. Combined with calcium antagonist: Benadryl hydrochloride tablets belong to angiotensin-converting enzyme inhibitor, when combined with calcium antagonist (such as verapamil), it can not only enhance the effect of blood pressure, but also have a protective effect on renal function. Benadryl hydrochloride tablets are indicated for the treatment of hypertension and heart failure. Adverse reactions include dizziness, headache, fatigue, dry cough, allergic reactions and so on. Benadryl Hydrochloride Tablets are contraindicated in patients who are allergic to Benadryl Hydrochloride Tablets and its excipient components, and in patients with renal vascular stenosis. Benadryl hydrochloride tablets specific and which antihypertensive drugs to take in combination, need to be based on the patient’s auxiliary examination, medical history and so on to determine. Do not buy and take medication on your own, it is recommended to go to the hospital for a detailed examination and take medication as prescribed by the doctor.