Efficacy is the key to the survival and development of TCM, and it is precisely the untold secret of TCM – the dosage – that restricts efficacy. To improve the efficacy, it is crucial to clarify the relationship between the dosage and the efficacy of Chinese medicine. Only a heavy dose of medicine can save the disease in a moment and help the dying. If the dose is too small, for acute and critical illnesses, it is a drop in the bucket, which will not help. At present, the clinical use of drugs has a tendency to increase, the reason is that the Chinese Pharmacopoeia “the amount of drugs, generally according to the previous wild drugs, but now almost all of the use of artificial cultivation and breeding of drugs, because of its short growth period, and the use of growth hormones, chemicals, etc., and its active ingredients than the wild drugs have significantly decreased, and because the quality of drugs has changed, the dosage should also be increased accordingly! Chinese medicine in large doses applied in Chinese medicine clinical often have a superior performance. Deng Tietao, a national medical master, used 250 grams of astragalus to treat myasthenia gravis, Wang Chengbai, a famous doctor in the capital, used 300 grams of red peony to treat severe biliousness, and the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine treated pediatric diseases with the same amount of adult medicine, which was repeatedly effective. Professor Tong Xiaolin found that in the treatment of diabetic ketoacidosis, the conventional daily dose of 30 grams of Huang Lian was simply “mud and cattle into the sea”. He innovatively increased the dosage of Huanglian, in some cases to 120 grams per day, to rapidly lower blood sugar and improve symptoms.