Which medication is best for lowering blood pressure in essential hypertension depends on the severity of hypertension and the various complications and damage to target organs. Commonly used antihypertensive drugs include diuretics, beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors (ACEI) and angiotensin 2 receptor antagonists (ARB). 1. Diuretics: mainly furosemide, hydrochlorothiazide, etc., through the excess water out of the body to achieve the purpose of lowering blood pressure, applicable to high blood volume hypertension, such as congestive heart failure. 2. β-blockers: mainly propranolol, metoprolol, etc., through reducing myocardial contractility and impaired frequency to achieve the purpose of lowering blood pressure, applicable to high blood pressure with fast heart rate. 3. Calcium channel blockers: mainly nifedipine, amlodipine and so on, through reducing myocardial contractility and dilating blood vessels to achieve the purpose of antihypertensive, applicable to hypertension with large arterial resistance. 4. ACEI and ARB: mainly enalapril, captopril, chlosartan and valsartan, etc., mainly through the blocking of angiotensin effect to achieve the purpose of lowering blood pressure, because it can reduce proteinuria, suitable for mild renal insufficiency hypertension. All of the above drugs should be used under the guidance of professional physicians to avoid adverse reactions.