Penicillin sodium for injection does not usually cause elevated blood pressure. Adverse reactions to penicillin include: allergic reactions such as urticaria, leukopenia, interstitial nephritis, asthma attacks, and serum sickness type reactions; toxic reactions, such as convulsions, muscle clonus, coma, and severe psychiatric symptoms due to high cerebrospinal fluid concentrations of the drug; Hirschsprung’s reaction and therapeutic contradictions; and secondary infections such as penicillin-resistant S. aureus, gram-negative bacilli, or Candida. There is usually no effect on blood pressure. Penicillin is used as the drug of choice for the following infections: hemolytic streptococcal infections, Streptococcus pneumoniae infections, nonpenicillinase-producing staphylococcal infections, anthrax, Clostridium difficile infections, syphilis, leptospirosis, regurgitation fever, diphtheria, and use in combination with aminoglycosides in the treatment of Streptococcus oxysporus endocarditis. There is a history of penicillin allergy or penicillin skin test positive patients are prohibited, pregnant women only when necessary to use, breastfeeding women should be suspended breastfeeding, children and the elderly use of the drug is not clear. If you need to use penicillin sodium for injection and other penicillin drugs, it is recommended to consult a professional doctor and follow the doctor’s instructions to standardize the use of drugs.