The causes of pain below the heart fossa are more varied and may include heart disease, gastroesophageal reflux disease, peptic ulcers, and hepatobiliary disease. Below the heart fossa in medical terminology refers to the subxiphoid process, the upper abdomen. The organs adjacent to this area are the heart, lower esophagus, stomach, gallbladder and left lobe of the liver, so disorders of these organs may cause the painful sensation. Diseases that may be associated with pain below the heart fossa are as follows: 1. Cardiovascular system diseases: coronary heart disease (angina pectoris, heart attack, etc.) can cause myocardial ischemia and hypoxia, and the clinical manifestation is chest tightness and chest pain. The typical site of chest pain is behind the sternum, but those who are not typical can also show pain below the heart fossa If the pain below the heart fossa is mostly related to exertion, emotional excitement, full meals, etc., and can be relieved by rest or nitroglycerin inhalation, with previous hyperlipidemia, diabetes, etc., the patient should be highly suspected of pain below the heart fossa caused by coronary heart disease. It can be identified by laboratory tests, electrocardiogram, coronary CT or coronary angiography, etc. 2, digestive system diseases: gastroesophageal reflux disease, peptic ulcer and biliary tract diseases may cause pain under the heart fossa. Gastroesophageal reflux disease is caused by the reflux of gastroduodenal contents into the esophagus causing discomfort. It is often accompanied by acid reflux and a feeling of heartburn, and is worse when lying down or when abdominal pressure is elevated. Peptic ulcers often occur in the stomach and duodenum, and patients generally complain of epigastric pain. However, digestive disorders are not significantly related to exertion, but are influenced by feeding and antacid therapy, etc. Upper abdominal discomfort is also caused by lesions of the left lobe of the liver or gallbladder. This can be clarified by barium meal examination, gastrointestinal endoscopy or ultrasound. Since there are more organs below the heart fossa, patients should not diagnose themselves with medication based on symptoms alone, and regular hospital consultation is recommended.