Eight-year-old girls still wet their pants may be sleep-wake dysfunction, abnormal bladder function, family genetics and other factors. 1. Sleep-wake dysfunction: ① insufficient nerve impulses from bladder filling to induce awakening; too deep sleep, failure to awaken. ② Nocturnal polyuria: the kidneys of some children with enuresis produce large amounts of urine at night, exceeding the maximum bladder capacity. It may be related to insufficient secretion of antidiuretic hormone by the pituitary gland at night. 2. Abnormal bladder function: mainly the decrease of bladder capacity caused by over-excitation of the detrusor muscle at night, resulting in frequent urination and low urine volume per time. 3. Family inheritance: family inheritance of about 62% of children with enuresis have parents or other relatives who have had a history of similar diseases, indicating that the disease may have a genetic predisposition. 4. Other: such as diabetes, depression and sleep apnea may also be associated with enuresis. Eight-year-old girls who appear to wet their pants are advised to go to the hospital in time for active treatment.