In clinical practice, patients or family members often ask similar questions, which is actually very difficult to give an accurate answer. There are many factors affecting the prognosis of patients, such as the stage of the disease, the malignancy of the cancer, whether the surgery is standard or radical enough, whether the postoperative chemotherapy is standardized and timely, whether the drugs are sensitive, and the patient’s physical and mental status, all of which will affect the disease regression in one way or another. Gastric cancer is a very heterogeneous malignant tumor, and the so-called heterogeneity means that there are many subtypes of tumor cells with different biological behaviors, sensitivity to drugs, growth patterns, and so on. In the case of gastric cancer patients, it means that the cancer cells in the same patient’s gastric cancer are all independent individuals and behave in different ways. For different gastric cancer patients, even with the same gender, age, location and stage, the same doctor’s consultation, the same surgery and chemotherapy regimen, the final prognosis is completely different. With the improvement of treatment level in recent years, both surgical techniques and chemotherapy drugs have been greatly improved, and the 5-year survival rate is also gradually increasing, and the 5-year survival rate of good domestic treatment units is suspected to reach more than 60%. If there is no recurrence and metastasis in 5 years, it is basically considered as clinical cure, and the probability of complete cure is even higher. After radical surgery for this stage of gastric cancer, standard adjuvant chemotherapy is required, and it is generally recommended that XELOX regimen or SOX regimen be given for six months and eight cycles. The overall prognosis is good and there is a chance of cure. As for the specific survival period, it is impossible to give an answer, and there is no standard answer per se. When the disease is first diagnosed, it is better to go to oncology specialist or specialist specializing in gastric cancer treatment to complete standardized staging examination, and after clarifying the stage of the disease, standard treatment plan will be given. One is to ensure that the regional lymph nodes are completely cleared and the other is to pay attention to the observance of the tumor-free principle during surgery. Preoperative free peritoneal cytology is preferable, and if positive or suspicious, peritoneal thermoperfusion chemotherapy should be added to prevent or reduce the risk of peritoneal metastasis. There are often misconceptions in this regard, which even lead to serious consequences. For example, it is often thought that if the patient is treated in a specialized oncology hospital, he or she will be stimulated by the sight of the “tumor”, or will be “devastated” after knowing that he or she has cancer. In fact, this is too much worry. As adults, they have the basic ability to resist stress and will not break down so easily. If patients know that cancer is not so terrible and has a good chance to be cured, they will not have unnecessary fear, but will cooperate more actively with doctors’ treatment, which will play a positive role in promoting the overall treatment effect. If we keep hiding it, it will lead to excessive psychological burden of patients, and often “good intentions will do bad things”. In fact, they are not thinking about the fundamental problem, that is, whether the patient’s temporary mood is important or the treatment effect is important, that is, the primary and secondary conflicts are not clearly distinguished. Postoperative adjuvant therapy: It is recommended that according to the postoperative pathological stage, adjuvant chemotherapy should be completed if the patient’s physical condition allows and adjuvant chemotherapy is needed. As for the adjustment of chemotherapy regimen and dose, the treating doctor needs to give appropriate adjustment according to the patient’s physical condition and response. Do regular review: Post-operative review is very important. The main purpose of regular review is to detect suspicious conditions at an early stage, intervene or treat them early to improve the treatment effect and objectively maximize the patient’s survival. Adjust your mind and maintain good diet and living habits: this aspect requires patients to adjust their own psychological state, preferably not often in negative emotions, and learn to adjust themselves. Actively exercising and enhancing physical fitness is itself an important way to reduce the risk of recurrence.