Children’s hands and feet are hot after taking ibuprofen for fever, which is usually seen when the drug has not yet taken effect or when the condition is serious, when the temperature drop is not satisfactory, or when the care is not appropriate, and so on, and needs to be analyzed according to its situation. It is generally considered that an axillary temperature of more than 37.3 ℃ is fever, which is a common symptom of pediatric diseases, and can be seen in infectious diseases such as respiratory tract infections, but also in non-infectious diseases such as acute leukemia. For children with fever, when the body temperature exceeds 38.5 ℃ or due to fever produce obvious symptoms of discomfort, oral antipyretic drugs, such as ibuprofen for symptomatic antipyretic, when taking ibuprofen hands and feet hot, generally seen in the drug has not yet taken effect, the body temperature has not been lowered, we need to continue to observe, but also can be seen in the use of insufficient dose of drugs, can not be very good to play the role of antipyretic. In some more serious diseases, such as sepsis, intracranial infections, etc., high fever occurs, the above phenomenon. For children with fever such as wearing more clothing or thick wraps, after taking ibuprofen can also be hot hands and feet, such need to pay attention to reduce clothing and other increase heat dissipation, continue to monitor the body temperature, for observation. Children with fever after taking ibuprofen hands and feet hot, there may also be other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment. The above medication is in accordance with the doctor’s instructions.