When the human nasal mucosa is stimulated by cold air, sneezing accompanied by a large amount of clear nasal discharge may occur. Strictly speaking, this disease is cold air induced rhinitis, which is a kind of hypersensitivity rhinitis, that is, highly sensitive to cold air. The main reason is that cold air can stimulate a cell called mast cell, which releases some inflammatory mediators that can lead to some symptoms of allergic rhinitis. The treatment of this cold air-induced hypersensitivity rhinitis is similar to the treatment principle of allergic rhinitis in general. Because it is basically the same as the pathogenesis of allergic rhinitis, also for the release of inflammatory mediators from mast cells. Therefore, the treatment is to use some antihistamines, which can mainly block the mast cell degranulation and stop the release of inflammatory mediators.