Urine color has become darker has no relationship with taking calcium hydroxybenzenesulfonate, it may be caused by urine concentration, dietary factors, drug factors, liver and gallbladder diseases. The common dosage forms of calcium hydroxybenzenesulfonate include capsule, tablet, etc. The indications, adverse reactions and contraindications of different dosage forms are the same, and it is mainly used for the treatment of varicose vein syndrome and microvascular disease. During the use of the drug, occasional stomach discomfort, heartburn and other symptoms, allergic to the ingredients contained in this product, pregnant and lactating women should be prohibited from using this product. However, there is no information showing that the consumption of this product will change the color of urine. Changes in urine color are generally considered for the following reasons. 1. Concentration of urine: the darkening of urine color is considered to be due to drinking too little water or the weather is too hot, resulting in the body is in a state of dehydration, the kidneys will repeat the absorption of water in the use of urine, resulting in the concentration of urine, the urine color darker. 2. Dietary factors: consuming a lot of oranges, carotenoids and other foods can also make the urine darker in color. 3. Drug factors: patients who take vitamin B foods, can also make the urine color darker, after stopping the drug, it can be relieved. 4. Hepatobiliary diseases: such as cholestatic jaundice, can make the urine bilirubin rise, which leads to dark urine. In addition, there are many other reasons that can cause the urine to become darker in color, it is recommended that patients go to the hospital in time to exclude physiological factors, and then receive treatment as soon as possible.