Table 10 Classification of hematological toxicity of targeted therapies for renal cell carcinoma

Severity grading

Neutrophil count reduction

Thrombocytopenia

Anemia

Grade I

1.5×109/L to lower limit of normal

75×109/L to lower limit of normal

Hemoglobin 100 g/L to lower limit of normal

Class II

1.0×109 to 1.5×109/L

50×109 to 75×109/L

Hemoglobin 80 to 100 g/L

Grade III

0.5×109 to 1.0×109/L

25×109 to 50×109/L

Hemoglobin<80 g/L

Grade IV

<0.5×109/L

<25×109/L

Life-threatening, requiring urgent treatment

Grade V

Death