Most of the 13-valent vaccines do not cause reactions, some may cause local and systemic reactions. 1. Normally, there are no reactions after receiving the 13-valent pneumonia vaccine. If you are not allergic to any of the components of the vaccine, you will not have any adverse reactions after the vaccination. The so-called adverse reactions are caused by allergy to some of the components of the vaccine. 2. Local reactions, mainly occurring in the local area of the vaccination site, may appear local redness, swelling, hardness, pain, itching and other manifestations, but the general degree is relatively mild, there is a certain degree of self-limitation, no need to carry out special treatments, 3-5 days can be self-healing. 3. Systemic reactions, including fever, diarrhea, nausea and vomiting, limb pain, etc., if the degree of mild can be self-cured through rest, if the degree is more serious, seriously affecting the normal life, you need to seek medical treatment.