Involuntary movement of the toes may be caused by calcium deficiency, peripheral neuritis, muscle twitching disorder and other reasons. 1. Calcium deficiency: It is mainly caused by insufficient intake, malabsorption and excessive consumption of calcium. Patients may experience elevated neuromuscular excitability, which may result in involuntary toe movement. 2. Multiple peripheral neuritis: it may be caused by poisoning, nutritional and metabolic disorders, infection, etc. Usually, there are symmetrical sensory, motor and autonomic dysfunction in the distal limbs, which may lead to the phenomenon of involuntary movement of the toes. 3. Muscle twitching: it refers to involuntary twitching or strong contraction of the whole body or local groups of skeletal muscles, when stimulated by cold, high temperature and other stimuli, the muscles of the toes can appear twitching, and there will be the phenomenon of involuntary movement. Involuntary movement of the toes can also be seen in other diseases, it is recommended that patients go to the hospital in a timely manner, to clarify the cause of the disease and follow the doctor’s instructions for treatment, so as not to delay the condition.