Liver metastasis of rectal cancer is a manifestation of advanced stage, which may show symptoms such as jaundice and pain in liver area, and may also metastasize to lungs, bones and other places and show corresponding symptoms. Rectal cancer is a kind of malignant tumor originated from rectal mucosa epithelium, and rectal cancer combined with liver metastasis belongs to advanced stage. Research shows that the common distant metastatic site of rectal cancer is liver, and patients may have symptoms such as jaundice, pain in liver area, weight loss and fever. Besides liver metastasis, lung metastasis, bone metastasis and brain metastasis are also prone to occur in advanced stage, and patients will have corresponding symptoms such as difficulty in breathing, bone pain, dizziness and headache. Patients need to cooperate with doctors to take comprehensive treatment measures such as chemotherapy, targeted therapy, surgery, interventional therapy, radiotherapy and so on. To sum up, rectal cancer combined with liver metastasis is in advanced stage, and patients need to actively cooperate with doctors to carry out comprehensive treatment to control tumor development, improve quality of life, and improve patients’ prognosis.