Common excitatory amino acid receptor antagonists include memantine, ketamine, MK-801, etc . Memantine is a drug used for the treatment of moderate-to-severe Alzheimer’s disease. Memantine blocks neuronal damage caused by pathologically elevated glutamate concentrations by antagonizing the central NMDA receptor and blocking the binding of glutamate to this receptor. Memantine may cause dizziness, headache, diarrhea, constipation, and hypertension. Ketamine has the same mechanism of action as memantine and is able to inhibit NMDA receptors, but ketamine is mainly used for anesthesia for superficial and short procedures. Common adverse reactions include cardiac arrhythmia, nystagmus, elevated intraocular pressure, nausea and vomiting, and allergy. Other excitatory amino acid receptor antagonists include MK-801 and CPP. The selection of medication should be based on the doctor’s professional opinion.