The cause of spotting when staying up late is considered to be melasma caused by endocrine imbalance. Melasma is a common skin pigmentation, especially in middle-aged women. At this time, women may stay up late for a long time, which may cause the estrogen and progesterone levels in the body to be disturbed, thus stimulating the melanin cells to secrete melanin particles, while poor sleeping habits will promote the transit and proliferation of melanin particles. It is especially aggravated under sunlight and persistent, manifesting as yellowish-brown pigmented spots on the face and symmetrically distributed. The first choice of treatment is to avoid triggering factors, need to do a good job of sun protection, and need to maintain adequate sleep. If necessary, you can also choose the way of laser, so as to lighten the local spots. The symptoms of spotting when staying up late, patients should consult a doctor in time and follow the doctor’s instructions to give the corresponding treatment, not blindly use drugs.