Children can take azithromycin and cephalosporins at the same time, both drugs belong to the same antibiotic, but the antibacterial spectrum is not exactly the same. Azithromycin is a macrolide antibiotic, usually for Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella, etc. The treatment effect is better. Cephalosporin antibiotics are divided into four generations, the first and second generation of cephalosporins are more favorable to gram-positive bacteria, and the third and fourth generation of cephalosporins are more favorable to gram-negative bacteria. Cephalosporins are generally preferred when a child has symptoms of infection because they have fewer adverse effects than azithromycin. If it is clear that the child has both Mycoplasma pneumoniae or bacterial infections, both drugs can be used, but attention should be paid to cephalosporin allergy and azithromycin-induced vomiting, diarrhea and other discomforts. When the child has fever or cough and other symptoms of infection, it is recommended to use the medication under the guidance of a doctor, not blindly and indiscriminately, so as not to jeopardize the health.