From an immunological point of view, allergic rhinitis is an allergic inflammatory reaction caused by an imbalance between Th1 and Th2 immune responses due to abnormal immune responses caused by environmental factors acting on the organism in vitro, with the main immunopathological feature being a large infiltration of cells expressing Th2 cytokines in the tissues. During immune development, infection by certain pathogenic microorganisms can affect and immune homeostasis. Therefore, stimulation of developing children with appropriate environmental factors, especially microbial infections, may help to antagonize allergen-induced immune responses by stimulating cell-mediated protective immune responses and regulating the state of Th1 and Th2 immune homeostasis. Accordingly, the hygiene hypothesis in the pathogenesis of allergic rhinitis is proposed. The hygiene hypothesis has some clinical significance. Because of the immunoprotective effect of early infection, developing children may improve their ability to resist allergic disease by receiving appropriate infectious stimuli. The hygienic hypothesis can precisely explain my clinical finding that most patients with allergic rhinitis have a history of heavy antibiotic use in childhood. Therefore, when a child has a low fever or diarrhea, parents should not be too nervous because this is a good opportunity to exercise the child’s immune system, and should not immediately inject fluids at the first sign of abnormality.