Gene mutation in papillary thyroid cancer, commonly known as changes in certain substances in thyroid cells, such as high expression of oncogenes and absence of oncogenes, is also the root cause of cancer, and the common clinical causes include long-term iodine deficiency or excessive iodine intake of the patient, heredity, radiation exposure, long-term excessive secretion of thyroid-stimulating hormone, long-term drinking and smoking, etc. Thyroid cancer can have multiple gene mutations, and detecting gene mutations has little impact on the treatment of thyroid cancer patients, so it is not a mandatory test. If the thyroid cancer is in early stage, the test result of gene mutation usually does not affect the treatment plan. Papillary thyroid cancer is common and poses a health risk to patients. However, if the thyroid tumor can be removed at an early stage through surgical treatment, the efficacy can be remarkable. If the tumor is not completely removed, killing the remaining cancer cells through radiotherapy can also improve the treatment effect. Patients with papillary thyroid cancer should go to the hospital for examination in time and be treated under the guidance of doctors.