If bladder cancer is combined with cancer pain in the advanced stage, the pain grading is usually around grade 8-10, which is similar to the pain caused by childbirth or similar to acute renal colic, and this pain lasts longer and can seriously endanger the patient’s quality of life. In the advanced stage of cancer, patients do not need to restrict the application of pain medication, and pain medication can be given as needed to reduce patients’ pain and improve their quality of life. Pain in advanced stage of bladder cancer includes pain caused by cancer itself and pain sensation caused by metastasis of cancer, resulting in destruction of metastatic target organs. Either kind of pain can seriously affect patients’ quality of life, which can cause patients to be unable to sleep, cause depression, anxiety and even the tendency to live lightly, etc. Oral pain medication or intramuscular pain medication is given in the late stage to relieve patients’ symptoms, and no strict dose restriction is made. As long as patients can tolerate it, they can be treated with pain relief as needed, without having to endure cancer pain.