Clarithromycin taken for 14 days can usually eliminate mycoplasma, but some people may have poorer therapeutic effect. Generally speaking, if mycoplasma infection occurs, take Clarithromycin for standardized treatment, can get a better therapeutic effect in 2 weeks, is also commonly used in the clinic, after 14 days of application and then check, can be clear that mycoplasma infection is controlled or cured. However, it cannot be ruled out that some people have drug resistance, that is, they have used Clarithromycin to treat other diseases, and generally use a longer time or a larger dose, resulting in drug resistance, then the effect of Clarithromycin is significantly reduced when it is used again for treatment, resulting in failure to achieve the expected results. Therefore, it is recommended to consult a doctor and conduct drug sensitivity tests and use the medication according to the doctor’s instructions.