The increasingly rich material life of modern society has fully met the basic needs of people, but the unrestricted pursuit of high-heat, high-protein food to satisfy the appetite of the mouth, but also led to an increase in obesity, but also derived from coronary heart disease, type II diabetes and many other diseases. Diabetic foot The incidence of lower limb ischemia is 50% in patients with long-term diabetes, and the incidence of diabetic foot is 0.9%~1.7%. The World Health Organization (WHO) defines diabetic foot as a patient with diabetes mellitus with varying degrees of peripheral vascular and neuropathy leading to lower limb infection, ulceration and deep tissue destruction, which seriously affects the quality of life. In this regard, there are many different traditional treatments for diabetic foot (drugs, vascular bypass, endoluminal revascularization intervention and amputation, etc.), but still 1/3 of the patients cannot undergo surgery due to distal arterial occlusion and have to choose drug therapy to prolong their lives. In 2004, Miranville found that adipose stem cells could promote the increase of vascular growth factors, secrete anti-apoptotic factors and differentiate into vascular endothelial cells during tissue ischemia. Animal experiments found that local injection of adipose stem cells in a diabetic lower extremity ischemia model of nude mice injury revealed an increase in anti-microbial and angiogenic factors in the early inflammatory response compared to the untreated diabetic group, and when ischemia was driven down, the inflammatory cells entered at an appropriate time to stop and begin the tissue reconstruction phase. Researchers believe that the main reason for adipose stem cell treatment of diabetic ischemic wounds is its ability to promote the expression of VEGF (vascular endothelial growth factor) in plasma and local tissues, and that VEGF may have a role in accelerating wound repair and healing in the treatment of diabetic foot. The Hen lab study concluded that SVF (Stromal Vascular Fraction) in adipose stem cells could increase fibroblast proliferation and collagen synthesis in diabetic foot, thus producing an effective healing effect on the wound. Further clinical studies have demonstrated that SVF secretes growth factors and extracellular matrix to provide a better microenvironment for tissue regeneration, and that extensive implantation in clean wounds can accelerate wound repair. Therefore, adipose stem cells contained in fat are easy to obtain and have no tissue rejection, so in addition to facial filler rejuvenation treatment, it can be a good choice for stem cell therapy for depressions, proliferative scars and chronic wounds (diabetic ulcers, etc.).