Multi-resistance is a condition in which resistance to one drug is accompanied by resistance to two other drugs with different structures and mechanisms. Multi-resistance can be categorized into primary and secondary resistance. Primary resistance refers to insensitivity to the drug and resistance to the drug on first use. Secondary resistance is when a person is initially sensitive to a drug and develops resistance to the drug after a few courses of treatment. Common multi-resistant bacteria include Acinetobacter baumannii and Klebsiella pneumoniae, which are usually resistant to both cephalosporins, penicillins and other antibiotics. Multi-drug resistance is usually caused by long-term use or irrational use of antibiotic drugs, such as the elderly patients will recur bacterial infectious diseases, long-term use of antibiotic treatment leads to the body of the bacteria to produce drug resistance, the daily life must avoid the abuse of antibiotic drugs. It is recommended that patients should use drugs correctly under the guidance of a doctor to avoid the emergence of multi-drug resistance, such as the emergence of multi-drug resistance should consult a doctor in a timely manner.