Tetanus antitoxin is not a vaccine, but a biological agent, which is mainly used for the prevention and treatment of tetanus. Tetanus antitoxin is a kind of passive immunization made from tetanus toxoid. After injection of tetanus antitoxin, the human body can quickly obtain anti-tetanus antibody, so as to have the ability to remove tetanus toxin from the body. Tetanus antitoxin is a serum containing antibodies, which may cause allergic reaction after injection, so skin test is needed before injection to avoid allergy. Adverse reactions of tetanus antitoxin mainly include allergic reactions, such as skin itching, urticaria, localized swelling, erythema at the injection site, hard nodules, edema and other symptoms, and in severe cases, it can cause anaphylactic shock. Contraindications to tetanus antitoxin mainly include positive allergy test, prohibited when there is a change in the nature of the drug. Tetanus antitoxin precautions mainly include the need to do allergy skin test before injection; tetanus antitoxin injection needs to make detailed records; injection equipment and injection site should be strictly sterilized; need to do allergy test before injection. Tetanus antitoxin needs to be injected in accordance with the doctor’s instructions, and should not be used blindly on its own, so as not to cause adverse reactions.