The long blisters on the pubic area are considered to be caused by genital herpes, condyloma acuminatum, papular urticaria and other diseases, and need to be treated with different drugs according to different causes. 1. genital herpes: mainly for herpes simplex virus infection of urogenital as well as perianal skin mucosa and cause, can lead to the patient pubic blisters, itching and pain. Clinically, the main use of antiviral drugs for systemic treatment, such as acyclovir, vasiclovir, etc.; secondly, it can also be appropriate to use topical antiviral creams, such as 3% acyclovir cream, 1% pentoxifylline cream and so on. 2. Warts: also known as genital warts, is caused by human papillomavirus infection and sexually transmitted diseases, can lead to pubic skin pimples, papillae or cauliflower pattern superfluous organisms, scratching can also be caused by the appearance of blisters. You can apply 0.5% onychomycetin tincture, 5% imiquimod cream, 5% fluorouracil cream and other drugs, can play a certain therapeutic effect; secondly, you can also use high-frequency electrocautery, shear surgery and other methods of huge warts, extensive wart excision for treatment. 3. Pemphigus urticaria: It is mainly due to the contact of the pubic area with certain chemicals or allergens, which leads to the appearance of pemphigus urticaria, and can also cause local skin blisters, itching and other uncomfortable symptoms. It can be treated by applying topical corticosteroid preparations, such as dianabed cream, tretinoin econazole cream, etc. In severe cases, oral antihistamines can be taken for anti-allergy treatment. Once the long blisters of the pubic area appear, you need to go to the hospital in time, under the guidance of the doctor to standardize the treatment, do not self-medication.