Always rotten toe seam is common in vesicular tinea pedis, acute eczema and so on, need for specific diseases, take the appropriate drugs, such as glucocorticoids, 3% boric acid solution, etc., for treatment. 1. Eczema tinea pedis: this disease occurs in the toe seam, especially in the 3rd to 4 and 4 to 5 toes, the treatment can be externally 3% boric acid solution, 0.1% isha acridine and other wet compresses, to be exudate to reduce, and then give the powder treatment, such as zinc oxide powder, miconazole powder, etc., the skin is dry and externally antifungal treatment, such as ketoconazole ointment, etc.; the serious oral treatment of antifungal drugs, such as itraconazole, etc.. 2. Acute eczema: after the diagnosis of this disease, can be used externally 3% boric acid solution cold wet compress treatment, exudate reduction after the use of glucocorticosteroid therapy, such as hydrocortisone cream, dinexed cream, etc.; external use of calcium-modulated phosphatase inhibitors to reduce the adverse effects of glucocorticosteroids, such as pimecrolimus cream, etc.; itching is intense, can be taken orally antihistamines, such as chlortetracycline, cetirizine and so on. It is recommended that patients according to their own situation, to the regular hospital dermatology consultation, after a clear diagnosis, under the guidance of the doctor reasonable use of medication, not blindly self-medication.