The reasons for waking up around 4:00 in the morning are physiological and pathological, and pathology is mostly seen in insomnia and depression, which can be treated with medication and psychotherapy. 1. Physiological: If you go to sleep earlier in the night, 8 to 9 o’clock, wake up around 4 o’clock in the morning is a normal time to get up. You can go to bed a little later. 2. Insomnia: If you suffer from insomnia, you will have difficulty in maintaining sleep and wake up easily during sleep. You can take sedative-hypnotic drugs, such as zopiclone and alprazolam. Cognitive behavioral therapy for sleep should also be performed. 3. Depression: Symptoms of depression include early awakening, and by depressed state of mind and lack of pleasure. Antidepressants such as sertraline and venlafaxine can be taken. And with psychological treatment. If long-term sleep deprivation, should be timely medical consultation, clear causes of timely treatment, drugs should be used under the guidance of a physician.