Pain in the skin of the abdomen may be due to inflammation of the abdominal wall itself or to inflammation within the abdominal cavity. If there is inflammation in the abdominal wall, it shows redness, swelling, hard nodules or even pus under the skin. It is mainly caused by bacterial infection and can be treated with oral antibiotics, such as cefradine, cefixime, ciprofloxacin, etc. If there is abscess formation, the abscess also needs to be cut open, drained, and then the wound changed. If there is inflammation inside the abdominal cavity, it can also lead to pain in the skin of the patient’s abdomen, such as pain in the right lower abdomen in appendicitis, and localized pressure pain, rebound pain, and abdominal muscle tension when pressing the right lower abdomen with a physical examination of the hand. Diagnosis requires an ultrasound examination of the appendix, which can reveal inflammation of the appendix, peripheral exudation or internal fecal stone impaction. Once the diagnosis of acute appendicitis is clear, surgical treatment is required.