Direct bilirubin of 8.0 μmol/L during pregnancy may be normal, or it may be due to pathologic causes such as bile excretion disorders, hepatitis, etc., which need to be combined with other relevant tests and symptoms to determine whether liver damage exists. Direct bilirubin is an important indicator of liver function, and is an important diagnostic and differential indicator of hepatobiliary diseases. Its normal level is 0~6.8μmol/L. When the value is more than two times higher than the reference value, it has strong clinical significance. The presence of direct bilirubin 8.0 μmol/L may be related to diet and can be rechecked after a normal diet, but it may also be due to gallstones, hepatitis and other causes. Fasting is required for liver function tests, but if the test is performed after a meal, the bilirubin will be elevated. Different hospitals’ examination methods, testing equipment and other factors may lead to differences in the normal value, the specific report should be based on the reference value.