Normally, C-reactive protein is not high in patients with cytomegalovirus simplex pneumonia, but it may be elevated if the inflammatory response is intense or in combination with other pathogenic microorganisms. 1. Whether C-reactive protein is high in pneumonia needs to be determined on a case-by-case basis. In general, C-reactive protein is usually high in pneumonia caused by bacterial infections; in pneumonia caused by non-bacterial infections such as cytomegalovirus infections, C-reactive protein is usually not high, but it is still necessary to combine with routine blood tests, PCT or blood sedimentation to determine the severity of the disease and whether there is a combination of other pathogenic organisms. 2. Patients with cytomegalovirus pneumonia usually present with fever, headache, chills, body aches, weakness, etc. Most of them may be accompanied by cough, sputum, sore throat, etc. Some patients may have gastrointestinal discomfort. Diagnosis can be aided by other tests such as chest CT, cytomegalovirus gene, and cytomegalovirus antigen test. Cytomegalovirus pneumonia tends to progress rapidly, and patients need to seek prompt medical attention and standardized diagnosis and treatment.