Valsartan and amlodipine benzenesulfonate can be taken at the same time, and the combination of the two is a commonly used combination drug regimen for hypertension, but it should be used under the guidance of a doctor. Valsartan is an angiotensin receptor inhibitor (ARB) class of drugs, which can inhibit the effect of angiotensin vasoconstriction and promote aldosterone release, thus playing a role in lowering blood pressure; amlodipine benzenesulfonate is a dihydropyridine calcium antagonist (CCB), which promotes the dilatation of peripheral arteries, lowers blood pressure, and also has the effect of relieving angina pectoris. ARBs + dihydropyridine CCBs are a commonly used combination drug regimen for hypertension, so valsartan and amlodipine benzenesulfonate can be taken at the same time, and can be used for people with unsatisfactory blood pressure control or secondary hypertension treated with single drugs. It should be noted that valsartan should not be used in people with a history of allergy to this drug, as well as in pregnant and lactating women, and should not be combined with aliskiren among diabetic patients; dizziness, fatigue, hypotension, renal impairment, hyperkalemia, and other adverse reactions may occur after use. Amlodipine benzenesulfonate should not be used in persons with a history of hypersensitivity to this drug. There may be discomfort such as edema, headache, flushing and palpitations after use. Although the above two drugs can be used in combination, they should be used under the supervision of a doctor and a doctor should be consulted promptly if any discomfort occurs.