Barrett’s esophagus refers to Barrett’s esophagus, a type of gastroesophageal reflux disease. Barrett’s esophagus is a precancerous lesion of esophageal adenocarcinoma due to gastroesophageal reflux and acidic gastric juices, which leads to the lower esophagus, where there is a replacement of squamous epithelium by columnar epithelium, often accompanied by specific enterosis. The etiology of the disease is still unclear, but it is confirmed that it may be related to molecular genetic alterations. Symptoms such as heartburn sensation, heartburn and acid reflux are often present, and some patients may also experience difficulty in swallowing and retrosternal pain. Barrett’s esophagus generally requires lifestyle adjustments, such as abstaining from alcohol and smoking, fat people should pay attention to weight control, and appropriate treatment with medication, mainly proton pump inhibitors and gastrointestinal motivation drugs, such as omeprazole, pantoprazole, itopride, domperidone, etc. Some patients may need to take endoscopic treatment or surgical treatment. For this disease should promptly go to the hospital gastroenterology department, by the doctor’s judgment, take the relevant examination to clarify the diagnosis and then treatment. Drugs should be taken under the guidance of a doctor.