Patients with multiple lacunar cerebral infarction who have sudden neurological deficit symptoms need to be hospitalized. Considering that the patient has a new-onset cerebral infarction, the patient should be given anti-platelet aggregation, anti-coagulation, fibre-lowering as well as treatments to activate blood circulation and remove blood stasis, scavenge oxygen radicals, and cerebroprotective treatment in the acute stage. After the acute treatment, if the patient has sequelae, follow-up rehabilitation treatment can also be carried out. For multiple lacunar cerebral infarcts, patients are considered to have heavy atherosclerosis, which is often accompanied by risk factors such as hypertension, hyperglycemia, and high homocysteine. After hospitalization, risk factors can be controlled under the guidance of physicians. For blood pressure, it is recommended to control the patient below 130/85mmHg. If the patient has diabetes mellitus, it is necessary to actively control fasting and postprandial blood glucose, and oral folic acid and vitamins can be taken when necessary to reduce serum homocysteine to prevent the recurrence of cerebral infarction, and patients with recurrent lacunar cerebral infarctions can have lacunar status.