Liddle syndrome is an autosomal dominant disorder with a lesion in the collecting ducts of the kidneys. It manifests as a clinical syndrome with increased sodium reabsorption from the renal collecting duct and increased potassium excretion and hydrogen secretion, leading to severe hypertension and disturbances in electrolyte and acid-base balance. diagnostic criteria for Liddle syndrome include the following: i. Clinical symptoms, hypertension and hypokalemia are very common symptoms, associated with increased reabsorption of sodium. It occurs mostly in adolescents, mostly with severe hypertension, and may have hypokalemia, manifested by muscle weakness of the limbs and episodic flaccidity. Second, laboratory tests may include high blood sodium, low blood potassium, metabolic alkalosis, etc., reduced aldosterone levels, and reduced renin activity. Third, aldosterone antagonists, such as spironolactone treatment is ineffective, and aminoglutethimide treatment, which inhibits sodium reabsorption by the renal tubules, is effective.