Sleeping with a lot of small pimples on the face may be related to acne, contact dermatitis, eczema and other factors, according to the different diseases to choose the appropriate drugs for treatment. 1. Acne: is a follicular sebaceous gland unit of chronic inflammatory skin disease, lesions at the beginning of the conical papules consistent with the hair follicles, lesions aggravated by the formation of inflammatory pimples, can be used externally retinoic acid cream, benzoyl peroxide and so on for treatment. 2. Contact dermatitis: the patient may belong to the allergic body, may be due to contact with allergens, sleep after a lot of small pimples on the face symptoms, accompanied by obvious itching phenomenon, need to be given to remove the causative agent, topical glycerol lotion coated to improve the symptoms. 3. eczema: is caused by a variety of internal and external factors of the superficial dermis and epidermal inflammation, clinical acute lesions with herpes mound, there is a tendency to ooze, can be used externally with glucocorticosteroids such as dianabed, etc. for treatment. Sleeping a lot of small pimples on the face may also have other reasons, need to consult the doctor in a timely manner, to clarify the cause, and give targeted treatment.