Neonatal impetigo treatment includes: 1, local treatment: topical antibiotic ointment on the site of impetigo, some ointments can not be used for newborns, so they should be applied under the guidance of a doctor. If the pustular rash is large, the pustular rash can be picked by the health care provider and then topical antibacterial drugs can be applied. 2. Systemic treatment: Because of the strong virulence of Staphylococcus aureus, it is easier to complicate sepsis, meningitis, septic arthritis and other diseases, so systemic antibiotic medication is needed, and it is recommended that a full course of treatment and standardized treatment be performed after detailed evaluation by a doctor.