Positive hepatitis B half-pair items 2 and 5 still have a certain possibility of being infected with the hepatitis B virus and turning into a hepatitis B patient. Positive item 2 and 5 of Hepatitis B two halves refers to positive hepatitis B surface antibody and hepatitis B core antibody, which generally indicates that the hepatitis B virus has been cleared and protective antibodies have been produced. However, if the patient uses some immunosuppressants for a long time, which makes the patient’s immune response lower, it may activate the hepatitis B virus and then transform into hepatitis B. Or the patient’s hepatitis B surface antibody amount is lower than that of the hepatitis B core antibody. Or if the patient’s hepatitis B surface antibody is low and the protection against hepatitis B virus is weak, he/she may be re-infected with hepatitis B virus and transformed into a hepatitis B patient. It is recommended that those who are positive for the 2nd and 5th items of Hepatitis B half-pair should have regular checkups on the quantification of Hepatitis B surface antigen, and if they find that their antibody loads are low, they should have timely supplementary vaccinations. In addition, they should also pay attention to avoid high-risk behaviors related to blood transmission, sexual transmission and mother-to-child transmission.