The survival time after chemotherapy for advanced lymphoma is related to the specific condition of patients and cannot be judged accurately, generally the 5-year survival rate is around 30%. Advanced lymphoma can be treated with standardized chemotherapy to inhibit the malignant proliferation of tumor cells, shrink the tumor foci, improve the quality of patients’ survival and prolong their life. Chemotherapeutic drugs available for patients with advanced lymphoma include methotrexate, fluorouracil, cyclophosphamide, paclitaxel, etc. Due to individual variability, there is no absolute most effective drug, and it is necessary to standardize the use of the drugs under the guidance of doctors, and consult doctors in time for the emergence of adverse reactions such as skin rashes, diarrhea, and vomiting, etc. The use of the drugs is prohibited for those with drug allergy. It is recommended that patients go to regular hospitals and actively receive standardized treatment.